PYY3-36 appetite
control nasal spray may be effective, yet still misused by consumers
Every once in a while, a prescription drug comes along that has
the potential to actually help people. In this article, I will be
discussing the PYY3-36 Appetite Control Nasal Spray made by a company
called Nastech. This is an upcoming prescription drug product still
in Phase II testing that could someday offer tremendous potential
to help people lose weight. But it's not all smooth sailing yet;
there are some potential dangers and pitfalls along the way. Those
will be discussed here as well.
The first thing to realize about this Nastech product is that it's
not really a prescription drug at all, in my view. It's a synthesized
version of the naturally-occurring hormone produced by the endocrine
system to regulate your appetite. It's almost misclassified as a
drug, although the way in which it will be used is certainly drug-like
in that it is designed to alter the biochemistry of the human body.
However, because it is a naturally occurring hormone present in
your body right now, it is likely to be far safer than typical prescription
drugs, which are based on synthetic chemicals foreign to the human
body. We have a lot of natural hormones available right now as nutritional
supplements including Melatonin, DHEA and even injectable human growth
hormone (although some would certainly argue the long-term safety
and efficacy of some of these as well).
But I believe that it is inherently safer to put natural hormones
into the human body rather than synthetic chemicals. So from the
get-go, PYY3-36 has one obvious advantage. It's something that we
already have in our bodies. So what's the promise of this prescription
drug?
The promise is that by inhaling this protein, your appetite will
be reduced. You will automatically eat less. And of course, you will
begin to lose weight even without trying. That's how the thinking
goes, anyway. It's a very seductive message, but it may in fact be
one that holds merit because more often than not, people who are
overweight fail to control their appetites.
They find it very difficult to ignore their own body chemistry and
ignore the hormones that are telling them to eat. If they had something
that could suppress that appetite, it would make it a lot easier
to lose weight and keep it off. This is similar to the promise of
the herbal-based, appetite control suppressant known as 'Hoodia'.
It’s from the Hoodia Gordonii succulent and it is now widely
sold as capsules or tinctures for appetite control.
This is the promise of the Nastech PYY3-36 Nasal Spray, and it is
potentially a very promising treatment for obesity (and would even
help those with diabetes as well). In fact, this could potentially
become a huge success as a prescription drug. It could be a blockbuster
seller.
But now let's look at some of the problems this product could bring
to the forefront if it becomes a huge success. The first problem,
as far as I see it, is that the Nastech company has chosen to partner
up with Merck as its marketing and distribution partner. This may
have seemed like a great choice years ago when this agreement was
reached between Nastech and Merck, but that was before the Vioxx
scandal, and that was before we saw many critics questioning the
ethics and credibility of Merck, myself included.
Now, this is my personal opinion, but I believe that through its
actions, Merck has proven itself to be an untrustworthy, unethical
company. In fact, I think it belongs on the list of the top five
most evil corporations in America, right along with EXXONMOBIL, McDonalds
Restaurants and Monsanto.
So partnering up with Merck is probably going to be a detriment
to the credibility of this drug in the long term. Why is that? Because
we've learned by observing Merck's behavior with Vioxx that the company
is capable of suppressing or spinning negative information about
its drug studies. And that makes a reasonable person question the
credibility of any positive drug studies associated with Merck
In other words, if this Nastech PYY Nasal Spray turns out to have
nothing but positive, glowing studies showing tremendous weight loss,
a thoughtful, rational person would obviously wonder, "Did Merck
suppress the negative studies on this product as well?" That's
certainly the question I would have.
So this association with Merck damages the credibility of what could
potentially be a very good product. And if Nastech were able to market
this through some other company other than Merck, it could actually
be to their benefit because now Merck has bad baggage. Distributing
your drug through Merck, in my opinion, is like tying an anchor around
your ankles and jumping into the river. You now have to swim even
harder just to stay afloat because your credibility has been questioned.
Then again, that's only my own opinion of Merck, and not everyone
agrees with that.
But let's say that Nastech manages to overcome this and Merck manages
to reclaim its credibility by reforming internal processes and making
a commitment to put safety above profits. So, even if this magical
transformation somehow occurs in Merck, what then? What about the
PYY3-36 Nasal Spray? Is it a good drug?
Well, that depends on how you use it. And unfortunately, the way
it is likely to be used by most Americans is as a replacement for
making healthy lifestyle changes. And again, this is unfortunate,
and it's no fault of the drug itself. It is a cultural issue and
an issue of personal discipline and personal responsibility. A lot
of people will say, "This is great! I can just take this drug,
inhale it three times a day, and I will automatically lose weight.
I don't have to stop eating pizza or ice cream, I don't have to start
engaging in physical exercise, and I don't have to start making healthy
food choices. I can just continue with my unhealthy, sedentary lifestyle
of junk foods and convenience foods, and still manage to lose weight
with this Nastech product."
I'm sure the product won't be marketed that way. It will be marketed
as an aid to help people who are making healthy lifestyle changes.
But nevertheless, this is not the way most people will ultimately
think about it, either consciously or unconsciously. People want
the easiest pathway to solving their weight problem, and they're
going to seek the path of least resistance. And if this drug causes
them to lose weight, it may in fact impair a person's ability to
learn from their health challenge and ultimately adopt a healthier
lifestyle for the long term.
You see, just because a person loses weight doesn't mean they're
getting good nutrition. A person could take a drug that causes weight
loss and end up being thin but still malnourished. In fact, they
are even more likely to be malnourished because they're eating less
overall food and they're probably not taking nutritional supplements
because they've never learned how to take care of their health.
So that’s the potential danger of a drug like Nastech's PYY
Nasal Spray. What is the potential upside? Well, it's very positive.
A responsible person who wants to make a lifelong change to their
health habits could use this in conjunction with healthy food choice
and personal responsibility. Hopefully they'll use it in combination
with advice from their physician or naturopath. For those people,
this PYY drug could be of tremendous assistance. It could enhance
their long-term health by helping them meet body fat goals and improve
their overall health standing. That could be a very positive use
of the drug.
As with many health-related tools, it can serve either good or evil,
depending on how it's used. It also depends on how it's marketed.
And that goes back to the ethics of the company doing the marketing,
which of course brings us back to Merck. You have to wonder about
the over-hyping and exaggerated health claims of drugs like Vioxx,
which were marketed as extremely safe anti-inflammatory drugs. We
now know those drugs are even more dangerous than the drugs they
were designed to replace: the over-the-counter, non-steroidal anti-inflammatory
drugs. You have to wonder how a drug like PYY Nasal Spray is going
to be positioned and marketed by a company like Merck. That's a legitimate
question.
So this Nastech PYY Nasal Spray is something I'll be watching very
carefully in the months ahead. If it ultimately earns safety approval
by the FDA, it could be a huge seller with unprecedented market impact.
It could generate billions of dollars of revenue for both Nastech
and Merck, and it could actually help people lose excess body fat,
and in doing so, reduce their risk of Type II diabetes, cardiovascular
disease and many other disorders.
At the same time, it could also be just another failed magic bullet.
It could be a quick-fix promise that fails to deliver, or that prevents
people from making the long-term lifestyle changes that would enhance
their health overall. I will definitely be watching this one. But
unlike most other prescription drugs, this is one "drug" that
I think holds the potential for enhanced safety because it's a naturally
occurring compound in the human body right now. That doesn't automatically
make it safe, but at least it's not something completely foreign
to the human body (like most over-the-counter drugs and prescription
drugs). |